DeMello effectively makes this point in one of the essays in Awareness.
“Life only makes sense when you perceive it as a mystery.” Anthony DeMello
This, he explains, is why we have such frustration in searching for “the meaning of life.” Reality, as we experience it, each of us, does not fit a formula or an ideology. As DeMello notes: “Every time you make sense out of reality, you bump into something that destroys the sense you made.” So what do we do then? Well, speaking from personal experience, the inclination is to get frustrated and either 1) stick with the old formula or ideology and consider the variants to be anomalous or misguided (i.e. the grumpy old fart syndrome, or worse); or 2) create a new formula or ideology – and then something else destroys that new sense I made of things. The latter process is like the endless “Rinse-Lather-Repeat.” loop printed on a shampoo bottle.
Thus, this friendly amendment to DeMello’s quote: “Live CAN only make sense in the long run when you perceive it as a mystery.” And it saves you a lot of shampoo.